/sbin/hdparm -B 255 /dev/sda
Set Advanced Power Management feature, if the drive supports it. A low value means aggressive power management and a high value means better performance. Possible settings range from values 1 through 127 (which permit spin-down), and values 128 through 254 (which do not permit spin-down). The highest degree of power management is attained with a setting of 1, and the highest I/O performance with a setting of 254. A value of 255 tells hdparm to disable Advanced Power Management altogether on the drive (not all drives support disabling it, but most do).
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